Synthesis and antimicrobial activity of pyrazole nucleus containing 2-thioxothiazolidin-4-one derivatives
نویسندگان
چکیده
منابع مشابه
Synthesis and Antimalarial Activity of Some New 3-phenyl-2- Thioxothiazolidin-4-one Derivatives
Objective: Current therapies to treat P. falciparum malaria are heavily reliant on artemisinin-based combinations. However, resistance to artemisinin has recently been identified, and resistance to key artemisinin partner drugs is already widespread. Therefore, there is an urgent need for new antimalarial drugs with improved attributes over older therapies. The objective of this research work i...
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In the present communication, a series of novel 1-(2-(3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-5-(pyridin-4yl)-1,3,4-oxadiazol-3(2H)-yl)-3-(aryl)prop-2-en-1-ones 5a-o have been efficiently synthesized and evaluated for their in vitro antimicrobial and cytotoxic activities. The results of antimicrobial study reveal the compounds 5f, 5g and 5k-m to be among the most potent antimicrobial agen...
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BACKGROUND Take-all of wheat, caused by the soil-borne fungus Gaeumannomyces graminis var. tritici, is one of the most important and widespread root diseases. Given that take-all is still hard to control, it is necessary to develop new effective agrochemicals. Pyrazole derivatives have been often reported for their favorable bioactivities. In order to discover compounds with high fungicidal act...
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Quinazolinones is an important chemical synthesis with different physiological significance and pharmacological utility. Reaction of anthranilic acid with benzoyl chloride in pyridine yielded 2-phenyl4H-benzo[d][1,3]oxazin-4-one, which on condensation reaction with the tryptophan in glacial acetic acid afforded 3-(1H-indol-3-yl)-2-(4-oxo-2-phenylquinazolin-3(4H)-yl) propanoic acid (2). Treatmen...
متن کاملSynthesis and Screening of Some New Isatin Containing Thiazole Derivatives for Antimicrobial Activity
In the present work, a series of new N’-[{5-(4-aryl) 1,3-thiazol-2yl}carbohydrazide-methyl]- 3(4-arylimino) indol-2-one analogs (5a-g) had heen synthesized from 3-(4-arylimino)-2-oxo- 1-indole-acetylthiosemicarbazide (4a-g) in ethanol, in the presence of phenacyl bromide or substituted phenacyl bromides. The compound 5e was characterized by its elemental analysis, IR, 1 HNMR and Mass Spectrosco...
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ژورنال
عنوان ژورنال: Arabian Journal of Chemistry
سال: 2017
ISSN: 1878-5352
DOI: 10.1016/j.arabjc.2013.05.029